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Tuesday, May 5, 2020 | History

3 edition of Regulation of cytolytic t lymphocyte generation in rat transplantation immunity found in the catalog.

Regulation of cytolytic t lymphocyte generation in rat transplantation immunity

Weiss, Arthur

Regulation of cytolytic t lymphocyte generation in rat transplantation immunity

by Weiss, Arthur

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  • 20 Currently reading

Published .
Written in English


Edition Notes

Statementby Arthur Weiss.
Classifications
LC ClassificationsMicrofilm 80623
The Physical Object
FormatMicroform
Paginationvii, 126 leaves
Number of Pages126
ID Numbers
Open LibraryOL3070741M
LC Control Number82168973

Compared to the control CAR-T (4H11) cells, both the CDCAR-T cells and the solHVEM-producing CAR-T cells produced significant therapeutic responses (n = 15; p Cited by: 1. Introduction. Allogeneic hematopoietic cell transplantation (HCT) represents an important therapy for many hematological and some epithelial malignancies and for a spectrum of nonmalignant diseases (Appelbaum, ).The development of novel strategies such as donor leukocyte infusions (DLI), nonmyeloablative HCT and cord blood transplantation (CBT) have helped expand the indications for.

The observation that infectious diseases of laboratory rats and mice have been on the decline for decades could lead one to a general sense of complacency regarding the plethora of pathogens to which these animals are susceptible. This chapter presents a wide, although certainly not exhaustive, scope of natural pathogens of laboratory rats and mice, and their effects on host physiology.   Various T cells and T cell-derived cytokines such as IL-2 and IFN-γ are upregulated early after transplantation. Later, ß-chemokines like RANTES (regulated upon activation, normal T cell expressed and secreted), IP, and MCP-1 are expressed, and this promotes intense macrophage infiltration of the allograft.

A/Prof Wayne Kimpton RECIRCULATION OF CYTOLYTIC T-CELLS FROM A SINGLE LYMPH-NODE DURING AN IMMUNE-RESPONSE TO ALLOGENEIC LEUKOCYTES The kinetics of lymphocyte recruitment into rat popliteal lymph nodes stimulated with varying doses of allogeneic lymphocytes or p. Because immunity to some antigens, including tumor antigens and human pathogenic viruses, may be better correlated with the cytolytic cellular immune response, we evaluated 16 non-Hodgkin's lymphoma patients immunized with autologous idiotypic ig molecules for changes in tumor-specific cytotoxic T-lymphocyte precursor (CTLp) frequency using.


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Regulation of cytolytic t lymphocyte generation in rat transplantation immunity by Weiss, Arthur Download PDF EPUB FB2

This chapter discusses the regeneration and proliferation in vitro of cytolytic T lymphocytes specific for msv-associated tumor antigens.

The cell-mediated immune response to syngeneic tumors induced by murine sarcoma virus (MSV) in the mouse involves the generation of cytolytic T lymphocytes (CTL) and of MSV-immune memory T cells. To study the role of self-reactive CD8+ T cells in tumor immunity and autoimmunity, we generated mice that bear a T-cell receptor transgene (TCR Tg) specific for the TRP-2() epitope.

Abstract. The potential of cyclosporin A (CsA) for the immunotherapy of allograft rejection and certain autoimmune disorders was evident in the first account by Borel et al. () of the immunosuppressive properties of the drug. It was clear from such early publications that CsA exerted a powerful and selective inhibitory action against T by: The LMC cycle and its role in transplantation immunity, Transplant Cantor, H., and Boyse, E.A.,Functional subclasses of T lymphocytes bearing different Ly antigens.

The generation of functionally distinct T cell subclasses and Benacerraf, B.,Multiple target cell killing by the cytolytic T lymphocyte and the Cited by: Publisher Summary. This chapter discusses the role of Ca 2+ as a potential second messenger for T and B lymphocyte activation and its relevance in DNA synthesis.

In a study described in the chapter, several T and B cell mitogens were added to purified mouse, pig, and rabbit splenocyte populations and to human peripheral blood lymphocytes. This chapter centers on adaptive or antigen-specific cellular responses to xenografts.

It emphasizes the nature of T-lymphocyte-dependent immunity to xenografts. Most of the concepts concerning T-cell responses to xenografts developed in the chapter are derived from rodent studies. When considering the T-lymphocyte response to non-self antigens, including xenografts, it is imperative to Author: Ronald G.

Gill. Recent reports have shown that in addition to the processes of elimination at the immature B-cell stage, B-cell anergy and regulation of T-cell help, self-reactive cells are also controlled by.

Using an HLA A*restricted T-cell clone reactive against pp65 from peripheral blood from a seropositive individual, we have mapped the position of the cytolytic T lymphocyte (CTL) epitope from HCMV pp65 to an amino acid by: Martz, E., and B.

Benacerraf. T-lymphocyte mediated cytolysis: Temperature dependence of killer cell dependent and independent phases and lack of recovery from the lethal hit at low temperatures. Cellular Immunol. Martz, E. Inability of EDTA to prevent damage mediated by cytolytic T-lymphocytes.

Cellular Immunol. One of many types of extracellular vesicles (EVs), exosomes are nanovesicle structures that are released by almost all living cells that can perform a wide range of critical biological functions. Exosomes play important roles in both normal and pathological conditions by regulating cell-cell communication in cancer, angiogenesis, cellular differentiation, osteogenesis, and by: 1.

Conversely, supplementation with Se increases lymphocyte proliferation, expression of the high‐affinity IL‐2R, cytolytic T lymphocyte (CTL) tumor destruction, and NK‐cell function in humans and increases lymphocyte proliferation, IL‐2R expression, and macrophage and Cited by: Upon infusion of T-allo10 and prior to donor hematopoietic stem cell transplantation (HSCT), the alloantigen-specific type 1 regulatory T cells are tolerant to the alloantigens and suppress alloreactive immune responses by donor CD4+ and CD8+ T cells.

Idiotype-specific T cell immunity. Generation of effector and suppressor T lymphocytes reactive with myeloma idiotype determinants. J Immunol. ; PMID: Abbas AK, Ratnofsky SE, Burakoff SJ. T lymphocyte mediated suppression of myeloma function in vitro.

Evidence for regulation of hapten-binding myelomas by. Alcantara, O., Obeid, L., Hannun, Y., Ponka, P and Boldt, D.H.

() Regulation of protein kinase C (PKC) by iron: effect of different iron compounds on PKC-beta and PKC-alpha expression and role of the 5' flanking region of the PKC-beta gene in the response to ferric transferrin. Bl The present invention is directed to universal T cells and their use in treating diseases and other physiological conditions.

More specifically, the present invention is directed to universal T cells and their use in treating treating B-lineage acute lymphoblastic leukemia (B-ALL) in particular and malignancy in general.

The universal T cells contain (i) nucleic acid encoding a chimeric Cited by: Indeed, we have previously shown that CD8+ T cells, IFN-γ, and cytolytic mechanisms are all important in the effective anti-rickettsial immune response.

8,9,27, The main target cells, endothelial cells, also play an important role in by: The immune system (the cells and the molecules responsible for immunity) is defined as part of the host's defence against destructive forces either from outside the body (e.g., bacteria, viruses and parasites) or from within (e.g., malignant and autoreactive cells)/5.

OBM Transplantation is an international peer-reviewed Open Access journal, which covers all evidence-based scientific studies related to transplantation, including: transplantation procedures and the maintenance of transplanted tissues or organs; assimilation of grafted tissue and the reconstitution of removed organs or parts of organs; transplantation of heart, lung, kidney, liver, pancreatic.

Bettelli E, Oukka M, Kuchroo VK. T(H) cells in the circle of immunity and autoimmunity. Nat Immunol.Sakaguchi S. Naturally arising Foxp3-expressing CD25+ CD4+ regulatory T cells in immunological tolerance to self and non-self.

Nature Immunol 6:Powrie F, Maloy KJ. Regulating the by: 4. Retiere, C. et al. Generation of cytomegalovirus-specific human T-lymphocyte clones by using autologous B-lymphoblastoid cells with stable expression of pp65 or IE1 proteins: a Cited by:.

The emergence of immune ‘checkpoint inhibitors’, blocking negative regulators of T-cell immunity opened new clinical applications of cancer immunotherapies. The more widely studied are cytotoxic T lymphocyte antigen 4 (CTLA-4) and programmed death receptor 1 (PD-1).Cited by: 5.

The recoverable CMV-specific cytolytic T lymphocyte (CTL) activity increased after each successive T cell infusion, and persisted at least 3 months after the last infusion, although long-term persistence of CD8 + T cell clones was not observed without a concurrent CD4 + helper response (Heslop and Rooney, ; Walter et al., ).

Gene and immunotherapeutic approaches to treat human malignant tumors are reviewed. Special attention is given to the different strategies of cancer gene therapy and to recent aspects of cytokine-supported tumor immunotherapy or tumor-specific vaccination.

The limitations of these therapy approaches are critically discussed especially with respect to immune escape mechanisms.